The Promise of Intra-Ovarian Platelet-Rich Plasma (PRP) for Ovarian Rejuvenation

Weight plays a critical role in reproductive health . Both overweight and underweight individuals may face challenges when trying to conceive, but for many patients struggling with obesity, even modest weight loss can significantly improve fertility outcomes. At Caperton Fertility Institute , with clinics in Albuquerque, NM, and El Paso, TX , we recognize the potential of new weight-loss therapies—such as GLP-1 receptor agonists—to support fertility and reproductive goals. How Weight Affects Fertility Excess body weight can affect fertility in multiple ways: Hormonal Imbalances – Obesity can disrupt the hypothalamic-pituitary-ovarian axis , leading to irregular menstrual cycles and ovulation problems. Insulin Resistance – Common in individuals with a higher BMI, insulin resistance can interfere with ovulation and increase the risk of polycystic ovary syndrome (PCOS) . Inflammation – Excess fat tissue produces inflammatory markers that may reduce egg quality, embryo development, and implantation success . Male Fertility – Elevated BMI in men is linked to lower testosterone, reduced sperm quality, and decreased libido. 👉 Even a 5–10% reduction in body weight can restore ovulation and improve the chances of natural conception or success with fertility treatments like IUI and IVF . What Are GLP-1 Agonists? GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications originally developed to treat type 2 diabetes. They mimic the natural GLP-1 hormone, which helps regulate blood sugar and appetite. Common GLP-1 medications include: Semaglutide (Ozempic®, Wegovy®) Liraglutide (Saxenda®) These medications have shown remarkable weight loss results in people with and without diabetes, making them a valuable tool for patients preparing for pregnancy. Benefits of GLP-1 Agonists for Fertility For patients struggling with obesity or PCOS, GLP-1 medications may support fertility by: Promoting sustainable weight loss Improving insulin sensitivity Helping regulate menstrual cycles Reducing symptoms of PCOS Lowering systemic inflammation As part of a preconception health plan , GLP-1 therapy may help create a healthier environment for conception and pregnancy. Considerations for Using GLP-1 Agonists in Fertility Treatment It’s important to use GLP-1 medications under the guidance of a fertility specialist . Key considerations include: Timing – GLP-1 agonists should generally be discontinued before trying to conceive , since safety in pregnancy has not yet been fully established. Medical Supervision – Safe and effective use requires oversight, often in combination with nutrition counseling and lifestyle changes . Individualized Plans – Not every patient is an ideal candidate. A comprehensive metabolic and fertility evaluation can help determine the best course of action. Weight Loss as a Path to Parenthood Weight loss isn’t just about numbers on the scale—it’s about optimizing your body for a healthy pregnancy . At Caperton Fertility Institute , we believe in a holistic, evidence-based approach to weight and fertility, combining: Advanced reproductive technologies (IUI, IVF, egg freezing) Metabolic health strategies The latest innovations like GLP-1 therapies Together, these tools can help patients achieve better fertility outcomes and increase their chances of bringing home a healthy baby. Next Steps: GLP-1 Agonists and Fertility Support If you are struggling with weight and fertility challenges or are interested in learning whether GLP-1 medications (Ozempic®, Wegovy®, Saxenda®) could play a role in your fertility journey, our team is here to help.  📍 Caperton Fertility Institute – Albuquerque, NM & El Paso, TX 📞 Call today or request your consultation online to explore personalized fertility solutions tailored to your health and family goals.

One of the most challenging moments in IVF treatment is when a healthy embryo is transferred into the uterus, but implantation does not occur. At Caperton Fertility Institute , we understand how frustrating and disheartening this can be. That’s why our team is exploring promising new therapies designed to improve endometrial receptivity and support successful embryo implantation. Among the most exciting innovations are: Intrauterine Platelet-Rich Plasma (PRP) Intrauterine Human Chorionic Gonadotropin (hCG) Peripheral Blood Mononuclear Cells (PBMCs) Each of these investigational treatments may help prepare the uterine environment to better support embryo implantation, especially for women who have experienced repeated implantation failure (RIF) . Intrauterine Platelet-Rich Plasma (PRP) Just as PRP has been studied for its regenerative potential in ovarian health, it may also improve the uterine lining (endometrium). PRP is prepared from a patient’s own blood and infused into the uterine cavity before embryo transfer. Potential benefits of intrauterine PRP for implantation include: Promoting growth of the endometrial lining Enhancing blood flow to the uterus Stimulating growth factors that may improve embryo receptivity For women with thin endometrium or repeated implantation challenges , PRP may offer a new opportunity for success. Intrauterine hCG Infusion Human chorionic gonadotropin (hCG) is a natural hormone produced by the early embryo. One of its roles is to signal the uterus to prepare for implantation. Administering a small dose of hCG directly into the uterine cavity before embryo transfer may mimic this natural signaling process. Studies suggest intrauterine hCG may: Improve implantation rates Enhance communication between the embryo and endometrium Support early pregnancy development Peripheral Blood Mononuclear Cells (PBMCs) PBMCs are immune cells—such as lymphocytes and monocytes—isolated from a patient’s blood. These cells can be activated in the lab and then infused into the uterine cavity prior to embryo transfer. The goal of PBMC therapy is to modulate the immune response , helping the maternal immune system accept the embryo. PBMC therapy has been explored in women with: Recurrent implantation failure (RIF) Suspected immune-related fertility challenges Emerging studies suggest PBMCs may increase implantation and pregnancy rates by improving the immune environment of the uterus. Who Might Benefit From PRP, hCG, or PBMC Therapies? These investigational intrauterine treatments are typically considered for women who have: Repeated implantation failure despite transferring healthy embryos Thin or unresponsive endometrial lining Suspected immune-related implantation challenges Because these treatments are still experimental , a detailed consultation is essential to determine whether they may be appropriate in your fertility journey. Caperton Fertility Institute’s Commitment At Caperton Fertility Institute in Albuquerque, NM, and El Paso, TX , we are committed to providing innovative, evidence-based fertility treatments. While intrauterine PRP, hCG, and PBMCs remain investigational, they represent promising new tools for patients facing implantation challenges. Our approach is always personalized —we carefully evaluate each patient’s history, test results, and goals before recommending advanced or experimental therapies. Moving Forward With Hope If you’ve experienced repeated implantation failure , we know how discouraging it can feel. At Caperton Fertility Institute , our team offers both cutting-edge science and compassionate care to help you move forward with confidence.  📍 Clinics in Albuquerque, NM & El Paso, TX 📞 Call today or request a consultation online to explore your fertility treatment options and discover whether intrauterine PRP, hCG, or PBMC therapy may be right for you.