Testosterone Therapy and Fertility in Transgender Men: What You Need to Know
Lee Caperton • August 8, 2024
Testosterone therapy in transgender men (individuals assigned female at birth who are transitioning to male) can significantly impact fertility. As transgender men embark on their gender-affirming journey, understanding the potential effects of testosterone on reproductive health is crucial. Here's what the data suggests.

Impact on Ovarian Function
Suppression of Ovulation:
Testosterone therapy generally suppresses ovulation, which can reduce the likelihood of spontaneous conception while on hormone therapy. Read more about ovulation suppression.
Ovarian Reserve:
There is some evidence that long-term testosterone use may impact the ovarian reserve (the number of viable eggs). However, the exact degree of this impact is not fully understood. Some studies suggest that testosterone may cause changes in ovarian morphology and function, potentially reducing fertility over time. Read more about ovarian function and testosterone.
2. Reversibility
Potential for Reversibility:
While testosterone can suppress ovulation and alter ovarian function, some studies have shown that fertility may return if testosterone is stopped. The extent to which fertility can be fully restored varies from person to person and depends on factors like age, duration of testosterone therapy, and overall reproductive health. Explore the potential for reversibility.
Egg Freezing Before Transition: Because the long-term impact of testosterone on fertility is not fully predictable, some transgender men choose to freeze their eggs before starting hormone therapy. This option is often recommended by healthcare providers to preserve future fertility potential.
3. Pregnancy after Testosterone Therapy
Pregnancy Outcomes:
There have been cases where transgender men have successfully conceived after discontinuing testosterone therapy. However, it may take some time for ovulation to resume, and overall fertility may be lower compared to pre-therapy levels.
4. Research Gaps
Limited Long-term Data:
There is a lack of long-term studies specifically assessing the fertility outcomes of transgender men after prolonged testosterone therapy. Most available data come from small studies or case reports, so generalizing findings can be challenging.
Testosterone therapy in transgender men can suppress ovarian function and potentially impact long-term fertility. While there is some potential for fertility to return after discontinuing testosterone, this is not guaranteed, and the degree of reversibility varies. Therefore, transgender men who may want to have biological children in the future should consider fertility preservation options like egg freezing before starting hormone therapy.
For more detailed information and references, please see the studies and articles linked throughout this blog.

When people talk about IVF, the focus is often on the medical side—medications, timelines, lab work, and success rates. What’s discussed far less often is the emotional experience , which can be just as intense as the physical process. If you’re feeling overwhelmed, conflicted, hopeful one moment and discouraged the next, you’re not doing IVF “wrong.” These emotional shifts are common—and normal. Here’s what many patients experience emotionally during IVF, even if no one warned them ahead of time. The Emotional Whiplash of Hope and Fear IVF often brings a unique combination of optimism and anxiety. Starting treatment can feel empowering—finally, something is happening. At the same time, that hope may feel fragile, especially if you’ve experienced infertility, loss, or disappointment before. Many patients describe: Feeling excited and terrified at the same time Guarding their optimism to avoid heartbreak Struggling to plan for the future because outcomes feel uncertain This emotional push and pull can be exhausting, and it’s one of the most common aspects of IVF that people don’t expect. Loss of Control (and Why It’s So Hard) IVF places much of the process outside your control—medication schedules, hormone levels, test results, and timing are often dictated by your body and the clinic. Even highly organized, resilient people may feel: Frustrated by last-minute changes Anxious while waiting for updates or phone calls Disconnected from their own body Feeling out of control can be one of the most emotionally challenging parts of IVF, especially for patients used to being proactive problem-solvers. The Two-Week Wait: An Emotional Rollercoaster The time between embryo transfer and pregnancy testing—often called the two-week wait—is widely considered the most emotionally difficult phase of IVF. During this time, patients may experience: Hyper-awareness of every physical sensation Replaying every step of the cycle in their mind Mood swings between confidence and despair Fear of testing too early—or testing at all This waiting period can feel isolating and all-consuming, even when everything medically has gone well. Unexpected Grief (Even During Treatment) IVF can bring up grief in unexpected ways—not just if a cycle fails, but throughout the process. You might grieve: The loss of a “normal” conception experience The version of parenthood you imagined Feeling carefree about pregnancy announcements or baby showers Even successful cycles don’t erase this grief. Many patients feel guilty for mourning while still feeling hopeful—but both emotions can exist at the same time. Relationship Strain and Emotional Distance IVF can impact relationships in ways couples don’t anticipate. Partners may cope differently—one may want to talk constantly, while the other withdraws. Common experiences include: Feeling emotionally out of sync with your partner Pressure to stay “strong” for each other Misunderstandings fueled by stress and fatigue Open communication and compassion—for yourself and your partner—are essential during treatment. You Are Not Weak for Feeling This Way One of the hardest emotional burdens of IVF is the belief that you should be handling it better. Many patients silently wonder why they feel so overwhelmed. The truth is: IVF is emotionally demanding . Feeling anxious, sad, angry, numb, or hopeful—sometimes all in the same day—does not mean you’re failing. It means you’re human. Supporting Your Emotional Well-Being During IVF While you can’t eliminate the emotional challenges of IVF, support can make a meaningful difference. Many patients benefit from: Counseling or fertility-focused therapy Support groups or trusted friends Mindfulness, journaling, or gentle movement Setting boundaries around social media and conversations Most importantly, give yourself permission to feel what you feel—without judgment. You Don’t Have to Carry This Alone IVF is more than a medical treatment; it’s an emotional journey that deserves understanding and compassion. If you’re struggling emotionally during IVF, know that you are not alone—and support is available. Your feelings are valid. Your experience matters. And taking care of your emotional health is just as important as every injection, appointment, and lab result along the way.

February is best known for hearts—whether it’s Valentine’s Day cards or American Heart Month. But beyond the decorations and candy, February is an important reminder to talk about heart health , and for individuals and couples trying to conceive, that conversation matters more than many people realize. Your heart and reproductive system are deeply connected. Taking care of your cardiovascular health can play a meaningful role in fertility, pregnancy outcomes, and even IVF success. How Heart Health Impacts Fertility The cardiovascular system is responsible for delivering oxygen and nutrients throughout the body—including to the reproductive organs. When heart health is compromised, blood flow can be affected, which may influence hormone balance, egg and sperm quality, and overall reproductive function. Conditions such as: High blood pressure Diabetes Obesity Elevated cholesterol can all impact fertility in both women and men. These conditions may also increase the risk of pregnancy complications, making heart health important not just for conception, but for a healthy pregnancy as well. Heart Health and Female Fertility In women, cardiovascular health is closely tied to hormonal regulation and ovulation. Poor circulation and chronic inflammation can interfere with: Regular ovulation Endometrial lining development Egg quality Additionally, conditions like polycystic ovary syndrome (PCOS) are often associated with insulin resistance and cardiovascular risk factors, highlighting the overlap between heart health and reproductive health. Heart Health and Male Fertility Heart health matters just as much for male fertility. Research has shown that men with cardiovascular risk factors may experience: Lower sperm count Reduced sperm motility Increased DNA fragmentation Lifestyle habits that support heart health—such as regular exercise, balanced nutrition, and avoiding tobacco—are often the same habits that support healthy sperm production. IVF, Pregnancy, and Cardiovascular Wellness For patients undergoing IVF, optimizing overall health before treatment can improve outcomes and reduce risks. A healthy cardiovascular system supports: Better response to fertility medications Improved uterine blood flow Lower risk of pregnancy-related complications such as preeclampsia or gestational hypertension That’s why fertility specialists often emphasize wellness and lifestyle optimization as part of fertility care. Simple Heart-Healthy Habits That Support Fertility The good news? You don’t need perfection—small, consistent changes can make a difference. Some heart-healthy habits that also support fertility include: Engaging in moderate physical activity most days of the week Eating a balanced diet rich in fruits, vegetables, lean proteins, and healthy fats Managing stress through mindfulness, therapy, or relaxation techniques Getting adequate sleep Avoiding smoking and limiting alcohol intake These steps benefit not only your heart, but your reproductive health as well. February: A Month to Focus on the Whole You Fertility care isn’t just about lab results or treatment cycles—it’s about supporting the whole person. February is the perfect time to reflect on how heart health fits into your fertility journey and to remember that caring for yourself now can have long-term benefits for your future family. If you’re trying to conceive, thinking about IVF, or simply have questions about how your overall health may impact fertility, a fertility specialist can help guide you with personalized care and evidence-based recommendations. Your heart—and your future—deserve that care. 💙

